Hormone replacement therapy and cardiovascular risk: do abnormalities of coagulation and fibrinolysis matter?
نویسندگان
چکیده
منابع مشابه
Postmenopausal hormone replacement therapy increases coagulation activity and fibrinolysis.
Hormone replacement therapy (HRT) appears to be cardioprotective in postmenopausal women; however, concerns exist over its thrombogenic effects. To address the effects of combined HRT on coagulation and fibrinolysis, we have measured circulating markers of these processes in a double-blind placebo-controlled trial. Forty-two healthy postmenopausal women aged 50 to 75 years received continuous c...
متن کاملHormone replacement therapy and cardiovascular disease.
Oestrogen alone probably confers a degree of protection against ischaemic heart disease and stroke and is appropriate for women requiring hormone replacement therapy (HRT) who have undergone hysterectomy. However, the cardiovascular effects of the progestogens used with oestrogen in the much larger number of women who have not undergone hysterectomy are unknown. Some widely used progestogens ha...
متن کاملPostmenopausal hormone replacement therapy and cardiovascular disease.
Cardiovascular disease is the leading cause of mortality in postmenopausal women in developed countries. A possible cardioprotective role of hormone replacement therapy (HRT) is suggested by epidemiologic studies of HRT and reduced risk of coronary heart disease, as well as by randomized trials of HRT and lipid subfractions. Estrogen has beneficial effects on the lipid profile, raising high-den...
متن کامل[Cardiovascular disease and hormone replacement therapy].
In Canada, cardiovascular disease (CVD) is the leading cause of mortality. In 1990, CVD killed 36,266 Canadian women. This represents 41 percent of deaths in women and is greater than all deaths due to cancer.' On average, Canadian women outlive men by seven years. During this period, CVD is second only to joint and bone dise'ase in limiting activities and reducing the autonomy of these women.2...
متن کاملPostmenopausal Hormone Replacement Therapy and Cardiovascular Disease
Heart disease is the leading cause of death among postmenopausal American women. Although early observational studies suggested that hormone replacement therapy (HRT) might decrease these risks, prospective, experimental studies have not supported these results. With the recent release of these data in the media, clinicians are receiving numerous questions concerning HRT. This article reviews t...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2008
ISSN: 0954-6820
DOI: 10.1111/j.1365-2796.2001.00796.x